Iontophoretic transdermal delivery of sumatriptan:: Effect of current density and ionic strength

被引：20

作者：

Femenía-Font, A

Balaguer-Fernández, C

Merino, V

López-Castellano, A

机构：

[1] Univ Cardenal Herrera, CEU, Dept Fisiol Farmacol & Toxicol, Moncada 46113, Spain

[2] Univ Valencia, Dept Farm & Tecnol Farmaceut, E-46100 Burjassot, Spain

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2005年 / 94卷 / 10期

关键词：

transdermal drug delivery; skin; percutaneous; permeation enhancers; iontophoresis;

D O I：

10.1002/jps.20447

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

lontophoretic transdermal delivery of sumatriptan was investigated in vitro. Among the conditions tested, 0.25 mA/cm(2) and low ionic strength (NaCl 25 mM) was the best experimental condition to increase its transport across the skin. The flux increased 385-fold respective to passive diffusion, thus resulting in a transdermal flux of sumatriptan of 1273 +/- 83 nmol/cm(2) h. (c) 2005 Wiley-Liss, Inc.

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页码：2183 / 2186

页数：4

相关论文

共 16 条

[1]

*AM SOC HLTH SYST, 2004, AHFS DRUG INF, P2441

[2]

CHARACTERIZATION OF THE PERMSELECTIVE PROPERTIES OF EXCISED HUMAN-SKIN DURING IONTOPHORESIS [J].

BURNETTE, RR ;

ONGPIPATTANAKUL, B .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (10) :765-773

[3]

IONTOPHORESIS OF NAFARELIN - EFFECTS OF CURRENT-DENSITY AND CONCENTRATION ON ELECTROTRANSPORT IN-VITRO [J].

DELGADOCHARRO, MB ;

RODRIGUEZBAYON, AM ;

GUY, RH .

JOURNAL OF CONTROLLED RELEASE, 1995, 35 (01) :35-40

[4]

High-performance liquid chromatographic determination of sumatriptan after in vitro transdermal diffusion studies [J].

Femenía-Font, A ;

Merino, V ;

Rodilla, V ;

López-Castellano, A .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2005, 37 (03) :621-626

[5]

FEMENIAFONT A, IN PRESS EUR J PHARM

[6]

IONTOPHORETIC DELIVERY OF AMINO-ACIDS AND AMINO-ACID DERIVATIVES ACROSS THE SKIN INVITRO [J].

GREEN, PG ;

HINZ, RS ;

CULLANDER, C ;

YAMANE, G ;

GUY, RH .

PHARMACEUTICAL RESEARCH, 1991, 8 (09) :1113-1120

[7]

Iontophoresis:: electrorepulsion and electroosmosis [J].

Guy, RH ;

Kalia, YN ;

Delgado-Charro, MB ;

Merino, V ;

López, A ;

Marro, D .

JOURNAL OF CONTROLLED RELEASE, 2000, 64 (1-3) :129-132

[8]

Iontophoretic drug delivery [J].

Kalia, YN ;

Naik, A ;

Garrison, J ;

Guy, RH .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (05) :619-658

[9]

CONVECTIVE SOLVENT FLOW ACROSS THE SKIN DURING IONTOPHORESIS [J].

KIM, A ;

GREEN, PG ;

RAO, G ;

GUY, RH .

PHARMACEUTICAL RESEARCH, 1993, 10 (09) :1315-1320

[10]

Iontophoretic delivery of ropinirole hydrochloride:: Effect of current density and vehicle formulation [J].

Luzardo-Alvarez, A ;

Delgado-Charro, MB ;

Blanco-Méndez, J .

PHARMACEUTICAL RESEARCH, 2001, 18 (12) :1714-1720