Effect of agmatine on the time course of brain inflammatory cytokines after injury in rat pups

被引：15

作者：

Feng, YZ ^{[1
]}

LeBlanc, MH ^{[1
]}

机构：

[1] Univ Mississippi, Med Ctr, Dept Pediat, Jackson, MS 39216 USA

来源：

AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES | 2003年 / 1009卷

关键词：

newborn; ischemia; hypoxia; imidazoline agonist;

D O I：

10.1196/annals.1304.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pro-inflammatory cytokines play an important role in brain injury. Agmatine reduces brain injury. Does agmatine act by reducing cytokines? Seven-day-old rat pups had the right carotid artery ligated and then were subjected to 2.5 hours of 8% oxygen. Agmatine (100 mg/kg) or vehicle was administered at 5 minutes after reoxygenation. Cytokines were measured in the cortex by enzyme-linked immunosorbent assay. Interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha) were significantly increased after reoxygenation. Agmatine had no effect.

引用

页码：152 / 156

页数：5

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