Effect of agmatine on the time course of brain inflammatory cytokines after injury in rat pups

被引：15

作者：

Feng, YZ ^{[1
]}

LeBlanc, MH ^{[1
]}

机构：

[1] Univ Mississippi, Med Ctr, Dept Pediat, Jackson, MS 39216 USA

来源：

AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES | 2003年 / 1009卷

关键词：

newborn; ischemia; hypoxia; imidazoline agonist;

D O I：

10.1196/annals.1304.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pro-inflammatory cytokines play an important role in brain injury. Agmatine reduces brain injury. Does agmatine act by reducing cytokines? Seven-day-old rat pups had the right carotid artery ligated and then were subjected to 2.5 hours of 8% oxygen. Agmatine (100 mg/kg) or vehicle was administered at 5 minutes after reoxygenation. Cytokines were measured in the cortex by enzyme-linked immunosorbent assay. Interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha) were significantly increased after reoxygenation. Agmatine had no effect.

引用

页码：152 / 156

页数：5

共 25 条

[21] CEREBRAL HYPOXIA-ISCHEMIA STIMULATES CYTOKINE GENE-EXPRESSION IN PERINATAL RATS [J].

SZAFLARSKI, J ;

BURTRUM, D ;

SILVERSTEIN, FS .

STROKE, 1995, 26 (06) :1093-1100

[22] Changes in expressions of proinflammatory cytokines IL-1β, TNF-α and IL-6 in the brain of senescence accelerated mouse (SAM) P8 [J].

Tha, KK ;

Okuma, Y ;

Miyazaki, H ;

Murayama, T ;

Uehara, T ;

Hatakeyama, R ;

Hayashi, Y ;

Nomura, Y .

BRAIN RESEARCH, 2000, 885 (01) :25-31

[23] Protective effect of aminoguanidine on hypoxic-ischemic brain damage and temporal profile of brain nitric oxide in neonatal rat [J].

Tsuji, M ;

Higuchi, Y ;

Shiraishi, K ;

Kume, T ;

Akaike, A ;

Hattori, H .

PEDIATRIC RESEARCH, 2000, 47 (01) :79-83

[24]

Xiao F., 1998, Society for Neuroscience Abstracts, V24, P1234

[25] Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion [J].

Zhang, FY ;

Casey, RM ;

Ross, ME ;

Iadecola, C .

STROKE, 1996, 27 (02) :317-323

← 1 2 3 →