Pluripotency and nuclear reprogramming

被引：106

作者：

Yamanaka, Shinya ^{[1
,2
]}

机构：

[1] Kyoto Univ, Ctr IPS Cell Res & Applicat, Sakyo Ku, Kyoto 6068507, Japan

[2] JST, CREST, Kawaguchi, Saitama 3320012, Japan

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2008年 / 363卷 / 1500期

关键词：

embryonic stem cell; induced pluripotent stem cell; transcription factor; retrovirus;

D O I：

10.1098/rstb.2008.2261

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Embryonic stem cells are promising donor cell sources for cell transplantation therapy, which may in the future be used to treat various diseases and injuries. However, as is the case for organ transplantation, immune rejection after transplantation is a potential problem with this type of therapy. Moreover, the use of human embryos presents serious ethical difficulties. These issues may be overcome if pluripotent stem cells are generated from patients' somatic cells. Here, we review the molecular mechanisms underlying pluripotency and the currently known methods of inducing pluripotency in somatic cells.

引用

页码：2079 / 2087

页数：9

共 127 条

[21] Acquiring signalling specificity from the cytokine receptor gp130 [J].