Testosterone deficiency: a risk factor for cardiovascular disease?

被引:134
作者
Jones, T. H. [1 ,2 ]
机构
[1] Barnsley Hosp NHS Fdn Trust, Robert Hague Ctr Diabet & Endocrinol, Barnsley, England
[2] Univ Sheffield, Acad Unit Diabet Endocrinol & Metab, Sheffield, S Yorkshire, England
关键词
CHRONIC HEART-FAILURE; CORONARY-ARTERY-DISEASE; ANDROGEN-DEPRIVATION THERAPY; HORMONE-BINDING GLOBULIN; ENDOGENOUS SEX-HORMONES; LOW SERUM TESTOSTERONE; MIDDLE-AGED MEN; PLASMINOGEN-ACTIVATOR INHIBITOR; ENDOTHELIAL PROGENITOR CELLS; PERIPHERAL VASCULAR-DISEASE;
D O I
10.1016/j.tem.2010.03.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Male gender is a major risk factor for premature cardiovascular death, a relationship not yet explained. Low testosterone in men is a risk factor for the metabolic syndrome and type 2 diabetes and is associated independently with individual components of the metabolic syndrome - visceral obesity, insulin resistance, hyperglycemia, hypertension and dyslipidemia. Epidemiological studies report increased mortality in men with low testosterone. Testosterone replacement in the short-term reduces waist circumference, cholesterol and circulating pro-inflammatory cytokines and improves insulin sensitivity and glycemic control in diabetics. Testosterone also has beneficial effects on cardiac ischemia, angina and chronic heart failure. This manuscript reviews the current evidence supporting a link between low testosterone and cardiovascular disease, highlighting the need for larger, longer-term studies.
引用
收藏
页码:496 / 503
页数:8
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