lunatic fringe regulates delta-notch induction of hypochord in zebrafish

被引：14

作者：

Appel, B ^{[1
]}

Marasco, P ^{[1
]}

McClung, LE ^{[1
]}

Latimer, AJ ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37235 USA

来源：

DEVELOPMENTAL DYNAMICS | 2003年 / 228卷 / 02期

关键词：

Notch; Delta; fringe; notochord; hypochord; gastrulation; zebrafish;

D O I：

10.1002/dvdy.10375

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Cells that occupy the midline of vertebrate embryos arise from a common population of precursors. Several lines of evidence indicate that Delta-Notch signaling regulates specification of midline precursors for different fates. We show that zebrafish midline precursors transiently express lunatic fringe, which encodes a glycosyltransferase that modifies Notch activity in response to its ligands, and that lunatic fringe function is required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain. (C) 2003 Wiley-Liss, Inc.

引用

页码：281 / 286

页数：6

共 49 条

[1] Delta-mediated specification of midline cell fates in zebrafish embryos [J].

Appel, B ;

Fritz, A ;

Westerfield, M ;

Grunwald, DJ ;

Eisen, JS ;

Riley, BB .

CURRENT BIOLOGY, 1999, 9 (05) :247-256

[2] Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation [J].

Aulehla, A ;

Johnson, RL .

DEVELOPMENTAL BIOLOGY, 1999, 207 (01) :49-61

[3] A ZEBRAFISH HOMOLOG OF THE DROSOPHILA NEUROGENIC GENE NOTCH AND ITS PATTERN OF TRANSCRIPTION DURING EARLY EMBRYOGENESIS [J].

BIERKAMP, C ;

CAMPOSORTEGA, JA .

MECHANISMS OF DEVELOPMENT, 1993, 43 (2-3) :87-100

[4]

Bishop SA, 1999, DEVELOPMENT, V126, P2993

[5] Glycosyltransferase activity of fringe modulates notch-delta interactions [J].

Brückner, K ;

Perez, L ;

Clausen, H ;

Cohen, S .

NATURE, 2000, 406 (6794) :411-415

[6]

Catala M, 1996, DEVELOPMENT, V122, P2599

[7]

Cleaver O, 2000, DEVELOPMENT, V127, P869

[8] Periodic Notch inhibition by lunatic fringe underlies the chick segmentation clock [J].

Dale, JK ;

Maroto, M ;

Dequeant, ML ;

Malapert, P ;

McGrew, M ;

Pourquie, O .

NATURE, 2003, 421 (6920) :275-278

[9]

de Celis JF, 1998, DEVELOPMENT, V125, P4617

[10] Maintenance of somite borders in mice requires the Delta homologue DII1 [J].

deAngelis, MH ;

McIntyre, J ;

Gossler, A .

NATURE, 1997, 386 (6626) :717-721

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