lunatic fringe regulates delta-notch induction of hypochord in zebrafish

被引：14

作者：

Appel, B ^{[1
]}

Marasco, P ^{[1
]}

McClung, LE ^{[1
]}

Latimer, AJ ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37235 USA

来源：

DEVELOPMENTAL DYNAMICS | 2003年 / 228卷 / 02期

关键词：

Notch; Delta; fringe; notochord; hypochord; gastrulation; zebrafish;

D O I：

10.1002/dvdy.10375

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Cells that occupy the midline of vertebrate embryos arise from a common population of precursors. Several lines of evidence indicate that Delta-Notch signaling regulates specification of midline precursors for different fates. We show that zebrafish midline precursors transiently express lunatic fringe, which encodes a glycosyltransferase that modifies Notch activity in response to its ligands, and that lunatic fringe function is required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain. (C) 2003 Wiley-Liss, Inc.

引用

页码：281 / 286

页数：6

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