Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2′-amino-α-L-LNA

被引：46

作者：

Hrdlicka, PJ ^{[1
]}

Kumar, TS ^{[1
]}

Wengel, J ^{[1
]}

机构：

[1] Univ So Denmark, Dept Chem, Nucle Acid Ctr, DK-5230 Odense, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 34期

关键词：

D O I：

10.1039/b506986f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Incorporation of a single pyrene-functionalized 29-amino-alpha-L-LNA monomer X into short DNA strands induces extraordinarily high binding affinity towards complementary DNA (up to 16 degrees C increase per modification), whereas labile duplexes, suitable as probes for targeting of double stranded DNA, are formed upon positioning of two monomers X in an interstrand +1 zipper motif.

引用

页码：4279 / 4281

页数：3

共 27 条

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