Creation of AMPA-silent synapses in the neonatal hippocampus

被引:93
作者
Xiao, MY [1 ]
Wasling, P [1 ]
Hanse, E [1 ]
Gustafsson, B [1 ]
机构
[1] Univ Gothenburg, Inst Physiol & Pharmacol, Dept Physiol, S-40530 Gothenburg, Sweden
关键词
D O I
10.1038/nn1196
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the developing brain, many glutamate synapses have been found to transmit only NMDA receptor-mediated signaling, that is, they are AMPA-silent. This result has been taken to suggest that glutamate synapses are initially AMPA-silent when they are formed, and that AMPA signaling is acquired through activity-dependent synaptic plasticity. The present study on CA3-CA1 synapses in the hippocampus of the neonatal rat suggests that AMPA-silent synapses are created through a form of activity-dependent silencing of AMPA signaling. We found that AMPA signaling, but not NMDA signaling, could be very rapidly silenced by presynaptic electrical stimulation at frequencies commonly used to probe synaptic function (0.05-1 Hz). Although this AMPA silencing required a rise in postsynaptic Ca2+, it did not require activation of NMDA receptors, metabotropic glutamate receptors or voltage-gated calcium channels. The AMPA silencing, possibly explained by a removal of postsynaptic AMPA receptors, could subsequently be reversed by paired presynaptic and postsynaptic activity.
引用
收藏
页码:236 / 243
页数:8
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