Nought May Endure but Mutability: Spliceosome dynamics and the regulation of splicing

被引：115

作者：

Smith, Duncan J. ^{[2
]}

Query, Charles C. ^{[1
]}

Konarska, Maria M. ^{[2
]}

机构：

[1] Albert Einstein Coll Med, Bronx, NY 10461 USA

[2] Rockefeller Univ, New York, NY 10065 USA

来源：

MOLECULAR CELL | 2008年 / 30卷 / 06期

关键词：

D O I：

10.1016/j.molcel.2008.04.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.

引用

收藏

页码：657 / 666

页数：10

相关论文

共 94 条

[1] Bimolecular exon ligation by the human spliceosome [J].

Anderson, K ;

Moore, MJ .

SCIENCE, 1997, 276 (5319) :1712-1716

[2] Mutational analysis identifies two separable roles of the Saccharomyces cerevisiae splicing factor Prp18 [J].

Bacíková, D ;

Horowitz, DS .

RNA, 2002, 8 (10) :1280-1293

[3] During in vivo maturation of eukaryotic nuclear mRNA, splicing yields excised exon circles [J].

Bailleul, B .

NUCLEIC ACIDS RESEARCH, 1996, 24 (06) :1015-1019

[4] Functional spliceosomal A complexes can be assembled in vitro in the absence of a penta-snRNP [J].

Behzadnia, Nastaran ;

Hartmuth, Klaus ;

Will, Cindy L. ;

Luehrmann, Reinhard .

RNA, 2006, 12 (09) :1738-1746

[5] A role for ubiquitin in the spliceosome assembly pathway [J].

Bellare, Priya ;

Small, Eliza C. ;

Huang, Xinhua ;

Wohlschlegel, James A. ;

Staley, Jonathan P. ;

Sontheimer, Erik J. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (05) :444-451

[6] Mechanisms of alternative pre-messenger RNA splicing [J].

Black, DL .

ANNUAL REVIEW OF BIOCHEMISTRY, 2003, 72 :291-336

[7] Allosteric cascade of spliceosome activation [J].

Brow, DA .

ANNUAL REVIEW OF GENETICS, 2002, 36 :333-360

[8]

Burge CB, 1999, RNA WORLD, P525

[9] A MECHANISM TO ENHANCE MESSENGER-RNA SPLICING FIDELITY - THE RNA-DEPENDENT ATPASE PRP16 GOVERNS USAGE OF A DISCARD PATHWAY FOR ABERRANT LARIAT INTERMEDIATES [J].

BURGESS, SM ;

GUTHRIE, C .

CELL, 1993, 73 (07) :1377-1391

[10] The Prp19p-associated complex in spliceosome activation [J].

Chan, SP ;

Kao, DI ;

Tsai, WY ;

Cheng, SC .

SCIENCE, 2003, 302 (5643) :279-282

← 1 2 3 4 5 6 7 8 9 10 →