Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty

被引：183

作者：

Ishida, Kazunari ^{[1
]}

Tsumura, Nobuhiro ^{[1
]}

Kitagawa, Atsushi ^{[1
]}

Hamamura, Sayaka ^{[1
]}

Fukuda, Koji ^{[1
]}

Dogaki, Yoshihiro ^{[1
]}

Kubo, Seiji ^{[2
]}

Matsumoto, Tomoyuki ^{[2
]}

Matsushita, Takehiko ^{[2
]}

Chin, Takaaki ^{[1
]}

Iguchi, Tetsuhiro ^{[1
]}

Kurosaka, Masahiro ^{[2
]}

Kuroda, Ryosuke ^{[2
]}

机构：

[1] Cent Hosp, Hyogo Rehabil Ctr, Dept Orthopaed Surg, Nishi Ku, Kobe, Hyogo 6512181, Japan

[2] Kobe Univ, Grad Sch Med, Dept Orthopaed Surg, Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

INTERNATIONAL ORTHOPAEDICS | 2011年 / 35卷 / 11期

关键词：

TRANSFUSION; REPLACEMENT; TRIAL; REINFUSION; TOURNIQUET; DRAINAGE; THERAPY; SALVAGE;

D O I：

10.1007/s00264-010-1205-3

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

This is a randomised controlled trial to examine whether intra-articular injection of tranexamic acid (TXA) decreases blood loss, as well as reducing leg swelling after total knee arthroplasty (TKA). We performed 100 TKA in osteoarthritis patients. At closure, a total of 2,000 mg/20 ml TXA was injected into the knee joint through a closed suction drain (TXA group). For the control group, the same volume of physiological saline was injected. The pre-operative condition of the patients, post-operative haemoglobin (Hb) levels, discharge volumes from drain, D-dimer and needs for transfusion were compared between these two groups. Furthermore, leg diameters (thigh, suprapatellar portion and calf girth) were measured pre- and post-operatively to investigate whether TXA has an influence on leg swelling after surgery. The results revealed that post-operative decrease in Hb level was significantly reduced in the TXA group. Furthermore, knee joint swelling after operation was significantly suppressed in the TXA group compared to the control group. The results revealed intra-articular administration of TXA decreased not only blood loss, but also knee joint swelling after TKA.

引用

页码：1639 / 1645

页数：7

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