Nontraditional cardiovascular risk factors

被引：52

作者：

Oparil, S

Oberman, A

机构：

[1] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Vasc Biol & Hypertens Program, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Med, Div Prevent Med, Birmingham, AL 35294 USA

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 1999年 / 317卷 / 03期

关键词：

cardiovascular risk factor; C-reactive protein; homocysteine; lipoprotein Lp (a); stress; insulin; angiotensin; oxidative stress;

D O I：

10.1097/00000441-199903000-00010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A number of newer, "nontraditional" cardiovascular risk factors have been identified based on recent studies of the pathogenesis of atherosclerosis and atherothrombotic cardiovascular events, These include chronic inflammation and its markers, such as C-reactive protein; homocysteine; oxidative stress or endothelial dysfunction; lipoprotein Lp (a); psychosocial factors, such as environmental stress and responsiveness to stress; plasma insulin levels and markers of insulin resistance; and activation of the renin-angiotensin system, which is in part a function of polymorphisms in genes for components of the system, such as angiotensinogen and the angiotensin II type 1 receptor, The strength of the associations of the newer risk factors with cardiovascular therapy are currently being tested. This review will briefly discuss evidence that these risk factors are related to cardiovascular disease.

引用

页码：193 / 207

页数：15

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