Direct catalytic asymmetric Mannich-type reaction of β-keto phosphonate using a dinuclear Ni2-Schiff base complex

被引：57

作者：

Chen, Zhihua ^{[1
]}

Yakura, Kenichiro ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

Shibasaki, Masakatsu ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 15期

关键词：

D O I：

10.1021/ol800965t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct catalytic asymmetric Mannich-type reactions beta-keto phosphonates are described. A homodinuclear Ni-2-Schiff base complex promoted the reaction at 0 degrees C, giving beta-amino phosphonates in up to 90% yield, 20:1 dr, and 99% ee. Control experiments suggested that two Ni metals are important for achieving high yield and stereoselectivity.

引用

页码：3239 / 3242

页数：4

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