A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology

被引:22
作者
Bochud, Murielle [1 ]
Chiolero, Arnaud [1 ]
Elston, Robert C. [2 ]
Paccaud, Fred [1 ]
机构
[1] Univ Inst Social & Prevent Med, Community Prevent Unit, Lausanne, Switzerland
[2] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA
关键词
D O I
10.1093/ije/dym186
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
引用
收藏
页码:414 / 416
页数:3
相关论文
共 28 条
[11]   Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of birth weight [J].
Lindsay, RS ;
Kobes, S ;
Knowler, WC ;
Hanson, RL .
HUMAN GENETICS, 2002, 110 (05) :503-509
[12]   No association of C677T methylenetetrahydrofolate reductase and an endothelial nitric oxide synthase polymorphism with recurrent pregnancy loss [J].
Makino, A ;
Nakanishi, T ;
Sugiura-Ogasawara, M ;
Ozaki, Y ;
Suzumori, N ;
Suzumori, K .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2004, 52 (01) :60-66
[13]   Methylenetetrahydrofolate reductase C677T and A1298C polymorphism and changes in homocysteine concentrations in women with idiopathic recurrent pregnancy losses [J].
Mtiraoui, N ;
Zammiti, W ;
Ghazouani, L ;
Braham, NJ ;
Saidi, S ;
Finan, RR ;
Almawi, WY ;
Mahjoub, T .
REPRODUCTION, 2006, 131 (02) :395-401
[14]   Parental origin-dependent, male offspring-specific transmission-ratio distortion at loci on the human X chromosome [J].
Naumova, AK ;
Leppert, M ;
Barker, DF ;
Morgan, K ;
Sapienza, C .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (06) :1493-1499
[15]   Imprinting and deviation from Mendelian transmission ratios [J].
Naumova, AK ;
Greenwood, CMT ;
Morgan, K .
GENOME, 2001, 44 (03) :311-320
[16]   Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis [J].
Nelen, WLDM ;
Blom, HJ ;
Steegers, EAP ;
den Heijer, M ;
Eskes, TKAB .
FERTILITY AND STERILITY, 2000, 74 (06) :1196-1199
[17]   Genetic risk factor for unexplained recurrent early pregnancy loss [J].
Nelen, WLDM ;
Steegers, EAP ;
Eskes, TKAB ;
Blom, HJ .
LANCET, 1997, 350 (9081) :861-861
[18]   Limits to causal inference based on mendelian randomization: A comparison with randomized controlled trials [J].
Nitsch, D ;
Molokhia, M ;
Smeeth, L ;
DeStavola, BL ;
Whittaker, JC ;
Leon, DA .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2006, 163 (05) :397-403
[19]   A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss [J].
Parle-McDermott, A ;
Pangilinan, F ;
Mills, JL ;
Signore, CC ;
Molloy, AM ;
Cotter, A ;
Conley, M ;
Cox, C ;
Kirke, PN ;
Scott, JM ;
Brody, LC .
MOLECULAR HUMAN REPRODUCTION, 2005, 11 (07) :477-480
[20]   The analysis of parental origin of alleles may detect susceptibility loci for complex disorders [J].
Paterson, AD ;
Naimark, DMJ ;
Petronis, A .
HUMAN HEREDITY, 1999, 49 (04) :197-204