The role of oocyte transcription, the 5′UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization

被引：91

作者：

Saunders, C ^{[1
]}

Cohen, RS ^{[1
]}

机构：

[1] Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA

来源：

MOLECULAR CELL | 1999年 / 3卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1097-2765(00)80173-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The establishment of the major body axes of the Drosophila egg and future embryo requires strict regulation of gurken mRNA and protein localization. Here, we show that grk mRNA and protein localization is dependent on synthesis of grk transcripts in the oocyte nucleus and on RNA localization elements in the 5' portion of the transcript. We also show that gurken mRNA and protein localization is dependent on region-specific translation of gurken transcripts and identify K10 as a probable negative regulator of gurken translation.

引用

页码：43 / 54

页数：12

共 60 条

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