Halitulin, a new cytotoxic alkaloid from the marine sponge Haliclona tulearensis

被引：81

作者：

Kashman, Y ^{[1
]}

Koren-Goldshlager, G

Gravalos, G

Schleyer, M

机构：

[1] Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel

[2] PharmaMar SA, Madrid, Spain

[3] Oceanog Inst, Durban, South Africa

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(98)02467-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Halitulin (2), a novel bisquinolinylpyrrole has been isolated from the sponge Haliclona tulearensis. Its structure was elucidated mainly on the basis of spectroscopic data as well as chemical modifications. Halitulin was found to be cytotoxic against several tumor cells: P-388, A-549, HT-29 and MEL-28 in concentrations of 12-25 ng/ml. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：997 / 1000

页数：4

共 16 条

[1] PAPUAMINE, AN ANTIFUNGAL PENTACYCLIC ALKALOID FROM A MARINE SPONGE, HALICLONA SP
BAKER, BJ
SCHEUER, PJ
SHOOLERY, JN
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (03) : 965 - 966
[2] Haliclonacyclamines A and B, cytotoxic alkaloids from the tropical marine sponge Haliclona sp.
Charan, RD
Garson, MJ
Brereton, IM
Willis, AC
Hooper, JNA
[J]. TETRAHEDRON, 1996, 52 (27) : 9111 - 9120
[3] HALICLONADIAMINE, AN ANTIMICROBIAL ALKALOID FROM THE SPONGE HALICLONA SP
FAHY, E
MOLINSKI, TF
HARPER, MK
SULLIVAN, BW
FAULKNER, DJ
PARKANYI, L
CLARDY, J
[J]. TETRAHEDRON LETTERS, 1988, 29 (28) : 3427 - 3428
[4] BIOACTIVE MARINE METABOLITES .29. HALICLAMINE-A AND HALICLAMINE-B, CYTOTOXIC MACROCYCLIC ALKALOIDS FROM A SPONGE OF THE GENUS HALICLONA
FUSETANI, N
YASUMURO, K
MATSUNAGA, S
HIROTA, H
[J]. TETRAHEDRON LETTERS, 1989, 30 (49) : 6891 - 6894
[5] Haliclorensin, a novel diamino alkaloid from the marine sponge Haliclona tulearensis
Koren-Goldshlager, G
Kashman, Y
Schleyer, M
[J]. JOURNAL OF NATURAL PRODUCTS, 1998, 61 (02): : 282 - 284
[6] Storniamides A-D: Alkaloids from a patagonian sponge Cliona sp
Palermo, JA
Brasco, MFR
Seldes, AM
[J]. TETRAHEDRON, 1996, 52 (08) : 2727 - 2734
[7] Pretseh E, 1983, TABLES SPECTRAL DATA
[8] New lamellarin alkaloids from an unidentified ascidian from the Arabian Sea
Reddy, MVR
Faulkner, DJ
Venkateswarlu, Y
Rao, MR
[J]. TETRAHEDRON, 1997, 53 (10) : 3457 - 3466
[9] POLYCITONE A AND POLYCITRIN-A AND POLYCITRIN-B - NEW ALKALOIDS FROM THE MARINE ASCIDIAN POLYCITOR SP
RUDI, A
GOLDBERG, I
STEIN, Z
FROLOW, F
BENAYAHU, Y
SCHLEYER, M
KASHMAN, Y
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (05) : 999 - 1003
[10] MANZAMINE-A, A NOVEL ANTITUMOR ALKALOID FROM A SPONGE
SAKAI, R
HIGA, T
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (20) : 6404 - 6405

← 1 2 →