Glycobiology of Plasmodium falciparum

被引:29
作者
Davidson, EA [1 ]
Gowda, DC [1 ]
机构
[1] Georgetown Univ, Dept Biochem & Mol Biol, Washington, DC 20057 USA
关键词
glycoproteins; proteoglycans; glycoconjugate; Plasmodium falciparum;
D O I
10.1016/S0300-9084(01)01316-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The human malaria parasite, Plasmodium falciparum, has as its only glycoconjugate GPI anchors. These structures, present in essentially all parasite surface proteins, are associated with disease pathology. In contrast, the parasite depends for essential recognition events on saccharides associated with host cell glycoproteins and proteoglycans. (C) 2001 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:601 / 604
页数:4
相关论文
共 14 条
[11]   NEUTRALIZING MONOCLONAL-ANTIBODIES TO GLYCOSYLPHOSPHATIDYLINOSITOL, THE DOMINANT TNF-ALPHA-INDUCING TOXIN OF PLASMODIUM-FALCIPARUM - PROSPECTS FOR THE IMMUNOTHERAPY OF SEVERE MALARIA [J].
SCHOFIELD, L ;
VIVAS, L ;
HACKETT, F ;
GEROLD, P ;
SCHWARZ, RT ;
TACHADO, S .
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1993, 87 (06) :617-626
[12]   Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: Activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties [J].
Tachado, SD ;
Gerold, P ;
Schwarz, R ;
Novakovic, S ;
McConville, M ;
Schofield, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :4022-4027
[13]   Plasmodium falciparum glycosylphosphatidylinositol-induced TNF-α secretion by macrophages is mediated without membrane insertion or endocytosis [J].
Vijaykumar, M ;
Naik, RS ;
Gowda, DC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (10) :6909-6912
[14]   Glycosylation and proteolytic processing of 70 kDa C-terminal recombinant polypeptides of Plasmodium falciparum merozoite surface protein 1 expressed in mammalian cells [J].
Yang, ST ;
Nikodem, D ;
Davidson, EA ;
Gowda, DC .
GLYCOBIOLOGY, 1999, 9 (12) :1347-1356