Assembling a clock for all seasons:: Are there M and E oscillators in the genes?

被引:169
作者
Daan, S
Albrecht, U
van der Horst, GTJ
Illnerová, H
Roenneberg, T
Wehr, TA
Schwartz, WJ
机构
[1] Univ Groningen, Zool Lab, NL-9750 AA Haren, Netherlands
[2] Max Planck Inst Expt Endocrinol, D-30625 Hannover, Germany
[3] Erasmus Univ, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands
[4] Acad Sci Czech Republ, Inst Physiol, CR-14220 Prague 4, Czech Republic
[5] Univ Munich, Inst Med Physiol, D-80336 Munich, Germany
[6] NIMH, Sect Biol Rhythms, Bethesda, MD 20892 USA
[7] Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA 01655 USA
关键词
evening/morning oscillators; circadian clock genes; pacemaker; photoperiodism; seasonal adjustment;
D O I
10.1177/074873001129001809
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The hypothesis is advanced that the circadian pacemaker in the mammalian suprachiasmatic nucleus (SCN) is composed at the molecular level of a nonredundant double complex of circadian genes (per1, cry1, and per2, cry2). Each one of these sets would be sufficient for the maintenance of endogenous rhythmicity and thus constitute an oscillator. Each would have slightly different temporal dynamics and light responses. The per1/cry1 oscillator is accelerated by light and decelerated by darkness and thereby tracks dawn when day length changes. The per2/cry2 oscillator is decelerated by light and accelerated by darkness and thereby tracks dusk. These M (morning) and E (evening) oscillators would give rise to the SCN's neuronal activity in an M and an E component. Suppression of behavioral activity by SCN activity in nocturnal mammals would give rise to adaptive tuning of the endogenous behavioral program to day length. The proposition-which is a specification of Pittendrigh and Daan's E-M oscillator model-yields specific nonintuitive predictions amenable to experimental testing in animals with mutations of circadian genes.
引用
收藏
页码:105 / 116
页数:12
相关论文
共 77 条
  • [51] FUNCTIONAL-ANALYSIS OF CIRCADIAN PACEMAKERS IN NOCTURNAL RODENTS .5. PACEMAKER STRUCTURE - CLOCK FOR ALL SEASONS
    PITTENDRIGH, CS
    DAAN, S
    [J]. JOURNAL OF COMPARATIVE PHYSIOLOGY, 1976, 106 (03): : 333 - 355
  • [52] PITTENDRIGH CS, 1981, HDB BEHAVIORAL NEURO, V4, P95
  • [53] Two period homologs:: Circadian expression and photic regulation in the suprachiasmatic nuclei
    Shearman, LP
    Zylka, MJ
    Weaver, DR
    Kolakowski, LF
    Reppert, SM
    [J]. NEURON, 1997, 19 (06) : 1261 - 1269
  • [54] Targeted disruption of the mPer3 gene:: Subtle effects on circadian clock function
    Shearman, LP
    Jin, XW
    Lee, CG
    Reppert, SM
    Weaver, DR
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (17) : 6269 - 6275
  • [55] Interacting molecular loops in the mammalian circadian clock
    Shearman, LP
    Sriram, S
    Weaver, DR
    Maywood, ES
    Chaves, I
    Zheng, BH
    Kume, K
    Lee, CC
    van der Horst, GTJ
    Hastings, MH
    Reppert, SM
    [J]. SCIENCE, 2000, 288 (5468) : 1013 - 1019
  • [56] Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript
    Shigeyoshi, Y
    Taguchi, K
    Yamamoto, S
    Takekida, S
    Yan, L
    Tei, H
    Moriya, T
    Shibata, S
    Loros, JJ
    Dunlap, JC
    Okamura, H
    [J]. CELL, 1997, 91 (07) : 1043 - 1053
  • [57] Photic resetting of intrinsic rhythmicity of the rat suprachiasmatic nucleus under various photoperiods
    Sumová, A
    Illnerová, H
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 274 (03) : R857 - R863
  • [58] Memory on long but not on short days is stored in the rat suprachiasmatic nucleus
    Sumova, A
    Travnickova, Z
    Illnerova, H
    [J]. NEUROSCIENCE LETTERS, 1995, 200 (03) : 191 - 194
  • [59] THE RAT SUPRACHIASMATIC NUCLEUS IS A CLOCK FOR ALL SEASONS
    SUMOVA, A
    TRAVNICKOVA, Z
    PETERS, R
    SCHWARTZ, WJ
    ILLNEROVA, H
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) : 7754 - 7758
  • [60] A light-independent oscillatory gene mPer3 in mouse SCN and OVLT
    Takumi, T
    Taguchi, K
    Miyake, S
    Sakakida, Y
    Takashima, N
    Matsubara, C
    Maebayashi, Y
    Okumura, K
    Takekida, S
    Yamamoto, S
    Yagita, K
    Yan, L
    Young, MW
    Okamura, H
    [J]. EMBO JOURNAL, 1998, 17 (16) : 4753 - 4759