Expression of adult T cell leukemia-derived factor in human brain and peripheral nerve tissues

被引：7

作者：

Asahina, M

Yamada, T

Yoshiyama, Y

Yodoi, J

机构：

[1] Chiba Univ, Dept Neurol, Chiba, Japan

[2] Kyoto Univ, Inst Virus Res, Kyoto 606, Japan

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 1998年 / 9卷 / 04期

关键词：

adult T cell leukemia-derived factor; astrocyte; hybridization in situ; Alzheimer's disease; RT-PCR;

D O I：

10.1159/000017044

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In both nonneurological and Alzheimer brains, we examined the localization of adult T cell leukemia-derived factor (ADF) by immunohistochemistry, that of its mRNA by in situ hybridization, and its semiquantitative mRNA analyses by RT-PCR. Anti-ADF antibody gave positive staining of white matter astrocytes and Schwann cells in the posterior root. Their intense and abundant staining was seen in Alzheimer brains. In situ hybridization for ADF mRNA showed identical signals in the white matter astrocytes. The evidence was also confirmed by KT-PCR analysis. These results suggest that redox regulation may play a role in Alzheimer pathology.

引用

页码：181 / 185

页数：5

共 18 条

[1] Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines [J].