The Role of Hypoxia Regulated microRNAs in Cancer

被引：31

作者：

McCormick, Robert ^{[1
]}

Buffa, Francesca M. ^{[1
]}

Ragoussis, Jiannis ^{[1
]}

Harris, Adrian L. ^{[1
]}

机构：

[1] Univ Oxford, Mol Oncol Labs, Weatherall Inst Mol Med, John Radcliffe Hosp, Oxford OX3 9DS, England

来源：

DIVERSE EFFECTS OF HYPOXIA ON TUMOR PROGRESSION | 2010年 / 345卷

关键词：

SULFUR CLUSTER BIOGENESIS; POSTTRANSCRIPTIONAL REGULATION; GENE-EXPRESSION; LET-7; MICRORNA; PROGNOSTIC-FACTOR; MESSENGER-RNAS; STEM-CELLS; MIR-210; TARGET; REPRESSION;

D O I：

10.1007/82_2010_76

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The molecular response of cancer cells to hypoxia is the focus of intense research. In the last decade, research into microRNAs (miRNAs), small RNAs which have a role in regulation of mRNA and translation, has grown exponentially. miR-210 has emerged as the predominant miRNA regulated by hypoxia. Elucidation of its targets points to a variety of roles for this, and other hypoxia-regulated miRNAs (HRMs), in tumour growth and survival. miR-210 expression correlates with poor survival in cancer patients, and shows promise for future use as a tumour marker or therapeutic agent. The role of miR-210 and other HRMs in cancer biology is the subject of this review.

引用

页码：47 / 70

页数：24

共 90 条

[1] let-7 microRNA functions as a potential growth suppressor in human colon cancer cells [J].