The role of HOX genes in the development and function of the female reproductive tract

被引：81

作者：

Taylor, HS ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, New Haven, CT 06520 USA

来源：

SEMINARS IN REPRODUCTIVE MEDICINE | 2000年 / 18卷 / 01期

关键词：

HOX; reproduction; homeobox genes; development;

D O I：

10.1055/s-2000-13478

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

HOX genes are a family of regulatory genes that encode transcription factors and are essential during embryonic development. These genes are highly conserved between species such that all metazoans possess a common genetic system for embryonic patterning. This system is conserved in the reproductive tract, where HOX genes are involved in the development of the mullerian system. The reproductive tract is unusual in that HOX genes continue to be expressed in the adult. HOX genes are essential both for appropriate reproductive tract development and for adult function. This article reviews the role of HOX genes in the development of the reproductive tract and the effect of HOX gene mutations on the development of the reproductive tract in both mice and humans. It then reviews the role and regulation of HOX genes in the adult function of the reproductive tract, specifically evidence that HOX genes are important for human endometrial development and receptivity.

引用

收藏

页码：81 / 89

页数：9

相关论文

共 74 条

[11] RETINOIC ACID AND PATTERN-FORMATION IN VERTEBRATES [J].

CONLON, RA .

TRENDS IN GENETICS, 1995, 11 (08) :314-319

[12]

Davis AP, 1996, DEVELOPMENT, V122, P1175

[13] Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster [J].

Del Campo, M ;

Jones, MC ;

Veraksa, AN ;

Curry, CJ ;

Jones, KL ;

Mascarello, JT ;

Ali-Kahn-Catts, Z ;

Drumheller, T ;

McGinnis, W .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (01) :104-110

[14] Haploinsufficiency of the HOXA gene cluster, in a patient with hand-foot-genital syndrome, velopharyngeal insufficiency, and persistent patent ductus botalli [J].

Devriendt, K ;

Jaeken, J ;

Matthijs, G ;

Van Esch, H ;

Debeer, P ;

Gewillig, M ;

Fryns, JP .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (01) :249-251

[15] THE BICOID PROTEIN DETERMINES POSITION IN THE DROSOPHILA EMBRYO IN A CONCENTRATION-DEPENDENT MANNER [J].

DRIEVER, W ;

NUSSLEINVOLHARD, C .

CELL, 1988, 54 (01) :95-104

[16] Abnormal uterine stromal and glandular function associated with maternal reproductive defects in Hoxa-11 null mice [J].

Gendron, RL ;

Paradis, H ;

HsiehLi, HM ;

Lee, DW ;

Potter, SS ;

Markoff, E .

BIOLOGY OF REPRODUCTION, 1997, 56 (05) :1097-1105

[17]

Goff DJ, 1997, DEVELOPMENT, V124, P627

[18] Deletions in HOXD13 segregate with an identical, novel foot malformation in two unrelated families [J].

Goodman, F ;

Giovannucci-Uzielli, ML ;

Hall, C ;

Reardon, W ;

Winter, R ;

Scambler, P .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (04) :992-1000

[19] Novel HOXA13 mutations and the phenotypic spectrum of hand-foot-genital syndrome [J].

Goodman, FR ;

Bacchelli, C ;

Brady, AF ;

Brueton, LA ;

Fryns, JP ;

Mortlock, DP ;

Innis, JW ;

Holmes, LB ;

Donnenfeld, AE ;

Feingold, M ;

Beemer, FA ;

Hennekam, RCM ;

Scambler, PJ .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (01) :197-202

[20] Synpolydactyly phenotypes correlate with size of expansions in HOXD13 polyalanine tract [J].

Goodman, FR ;

Mundlos, S ;

Muragaki, Y ;

Donnai, D ;

GiovannucciUzielli, ML ;

Lapi, E ;

Majewski, F ;

McGaughran, J ;

McKeown, C ;

Reardon, W ;

Upton, J ;

Winter, RM ;

Olsen, BR ;

Schambler, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (14) :7458-7463

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