Catalytic, asymmetric synthesis of cyanohydrin esters: The effect of anhydride structure on enantioselectivity

被引：24

作者：

Belokon, YN

Carta, P

North, M ^{[1
]}

机构：

[1] Kings Coll London, Dept Chem, London WC2R 2LS, England

[2] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 117813, Russia

来源：

LETTERS IN ORGANIC CHEMISTRY | 2004年 / 1卷 / 01期

关键词：

cyanohydrin; catalyst; asymmetric; ester; titanium; salen;

D O I：

10.2174/1570178043488617

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A bimetallic titanium(salen) complex has been shown to catalyse the asymmetric addition of potassium cyanide to aldehydes in the presence of a range of anhydrides. leading to cyanohydrin esters. Linear aliphatic anhydrides (acetic and propionic) gave products with higher enantiomeric purity than those obtained using pivalic or benzoic anhydrides.

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页码：81 / 83

页数：3

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