Recurrent Miscarriage

被引：256

作者：

Branch, D. Ware ^{[1
,2
]}

Gibson, Mark ^{[1
]}

Silver, Robert M. ^{[1
]}

机构：

[1] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT 84132 USA

[2] Intermt Healthcare, Salt Lake City, UT USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 363卷 / 18期

关键词：

MOLECULAR-WEIGHT HEPARIN; LOW-DOSE ASPIRIN; RANDOMIZED CONTROLLED-TRIAL; UTERINE ANOMALIES; HYSTEROSCOPIC METROPLASTY; REPRODUCTIVE OUTCOMES; PREGNANCY OUTCOMES; MATERNAL AGE; PLUS HEPARIN; FETAL LOSS;

D O I：

10.1056/NEJMcp1005330

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 32-year-old woman presents for evaluation after three consecutive miscarriages. Before these miscarriages, she had one successful pregnancy. The patient reports no medical problems or previous surgeries. In her first miscarriage, uterine bleeding and cramping started in the 7th week of gestation, and an ultrasonographic evaluation showed an empty gestational sac of 6 weeks' size. In her next pregnancy, she presented with a miscarriage in the 8th week. The third miscarriage was identified by ultrasonographic testing as a dead embryo measuring 7.5 weeks' size. How should her case be evaluated and managed?

引用

页码：1740 / 1747

页数：8

共 56 条

[11] Karyotype of the abortus in recurrent miscarriage [J].

Carp, H ;

Toder, V ;

Aviram, A ;

Daniely, M ;

Mashiach, S ;

Barkai, G .

FERTILITY AND STERILITY, 2001, 75 (04) :678-682

[12] SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage [J].

Clark, Peter ;

Walker, Isobel D. ;

Langhorne, Peter ;

Crichton, Lena ;

Thomson, Andrew ;

Greaves, Mike ;

Whyte, Sonia ;

Greer, Ian A. .

BLOOD, 2010, 115 (21) :4162-4167

[13] Does suppressing luteinising hormone secretion reduce the miscarriage rate? Results of a randomised controlled trial [J].

Clifford, K ;

Rai, R ;

Watson, H ;

Franks, S ;

Regan, L .

BRITISH MEDICAL JOURNAL, 1996, 312 (7045) :1508-1511

[14] Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss [J].

Craig, LB ;

Ke, RW ;

Kutteh, WH .

FERTILITY AND STERILITY, 2002, 78 (03) :487-490

[15] The relationship of the factor v Leiden mutation and pregnancy outcomes for mother and fetus [J].

Dizon-Townson, D ;

Miller, C ;

Sibai, B ;

Spong, CY ;

Thom, E ;

Wendel, G ;

Wenstrom, K ;

Samuels, P ;

Cotroneo, MA ;

Moawad, A ;

Sorokin, Y ;

Meis, P ;

Miodovnik, M ;

O'Sullivan, M ;

Conway, D ;

Wapner, RJ ;

Gabbe, SG .

OBSTETRICS AND GYNECOLOGY, 2005, 106 (03) :517-524

[16]

Duggan M, 2001, PATHOLOGY, V33, P292

[17] Genetic Counseling in Robertsonian Translocations der(13;14): Frequencies of Reproductive Outcomes and Infertility in 101 Pedigrees [J].

Engels, Hartmut ;

Eggermann, Thomas ;

Caliebe, Almut ;

jelska, Anna ;

Schubert, Regine ;

Schueler, Herdit M. ;

Panasiuk, Barbara ;

Zaremba, Jacek ;

Latos-Bielenska, Anna ;

Jakubowski, Lucjusz ;

Zerres, Klaus P. ;

Schwanitz, Gesa ;

Midro, Alina T. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2008, 146A (20) :2611-2616

[18]

Farquharson RG, 2002, OBSTET GYNECOL, V100, P1361

[19] Antiphospholipid syndrome in pregnancy: A randomized, controlled trial of treatment [J].

Farquharson, RG ;

Quenby, S ;

Greaves, M .

OBSTETRICS AND GYNECOLOGY, 2002, 100 (03) :408-413

[20] Low-molecular-weight heparin versus low-dose aspirin in women with one fetal logs and a constitutional thrombophilic disorder [J].

Gris, JC ;

Mercier, E ;

Quéré, I ;

Lavigne-Lissalde, G ;

Cochery-Nouvellon, E ;

Hoffet, M ;

Ripart-Neveu, S ;

Tailland, ML ;

Dauzat, M ;

Marès, P .

BLOOD, 2004, 103 (10) :3695-3699

← 1 2 3 4 5 6 →