Submicroscopic deletions in an acute myeloid leukemia case with a four-way t(8;11;16;21)

被引：11

作者：

Albano, F

Specchia, G

Anelli, L

Liso, A

Zagaria, C

Santoro, A

Mirto, S

Liso, V

Rocchi, M

机构：

[1] Univ Bari, Policlin, Dept Hematol, I-70124 Bari, Italy

[2] Univ Foggia, Foggia, Italy

[3] Univ Bari, DAPEG, Sez Genet, Bari, Italy

[4] Osped V Cervello, Dept Hematol, Palermo, Italy

来源：

LEUKEMIA RESEARCH | 2005年 / 29卷 / 07期

关键词：

RUNX1; CBFA2T1; acute myeloid leukemia; variant t(8; 21) rearrangement; submicroscopic deletions;

D O I：

10.1016/j.leukres.2004.12.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The t(8;21)(q22;q22) rearrangement is observed in about 15% of acute myelocitic leukemia (AML) cases, while variant t(8;21) translocations are detected in 6-10% of AML patients positive for the 5 ' RUNX1/3 ' CBFA2T1 fusion gene. We report a detailed molecular cytogenetic analysis of a four-way variant t(8;1 1;16;21)(q22; q14; q12; q22) performed by fluorescence in situ hybridization with specific BAC and PAC clones. The study demonstrated the loss of several megabases belonging to chromosomes 11 and 16 whereas no deletion was detected on der(21). These findings suggest that a precise breakpoint characterization could identify submicroscopic genomic deletions whose meaning remains to be defined. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：855 / 858

页数：4

共 22 条

[1]

Albano F, 2003, HAEMATOLOGICA, V88, P1076

[2] Genomic deletions on other chromosomes involved in variant t(9;22) chronic myeloid leukemia cases [J].