Development of new methodologies for the mass spectrometry study of bioorganic macromolecules

被引：64

作者：

Cristoni, S ^{[1
]}

Bernardi, LR ^{[1
]}

机构：

[1] Univ Milan, CISI, I-20090 Milan, Italy

来源：

MASS SPECTROMETRY REVIEWS | 2003年 / 22卷 / 06期

关键词：

macromolecules; mass spectrometry; bioorganic macromolecules; ESI; MALDI; no-discharge APCI; SSI;

D O I：

10.1002/mas.10062

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

In recent years, mass spectrometry has been increasingly used for the analysis of various macromolecules of biological, biomedical, and biochemical interest. This increase has been made possible by two key developments: the advent of electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) sources. The two new techniques produce a significant increase in mass range and in sensitivity that led to the development of new applications and of new analyzer designs, software, and robotics. This review, apart from the description of the status of mass spectrometry in the analysis of bioorganic macromolecules, is mainly devoted to the illustration of the more recent promising techniques and on their possible future evolution. (C) 2003 Wiley Periodicals, Inc.

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收藏

页码：369 / 406

页数：38

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