B cells in multiple sclerosis

被引：12

作者：

Burgoon, MP

Gilden, DH

Owens, GP

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Neurol, Denver, CO 80262 USA

[2] Univ Colorado, Hlth Sci Ctr, Dept Microbiol, Denver, CO 80262 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2004年 / 9卷

关键词：

multiple sclerosis; MS; B cells; antibodies; oligoclonal bands; review; CNS; central nervious system; neurologic disease;

D O I：

10.2741/1278

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The most common laboratory abnormality in multiple sclerosis (MS) is an increased amount of cerebrospinal fluid IgG and the presence of oligoclonal bands. Despite studies of the humoral response that suggest the involvement of an infectious agent or autoantigen in disease, the major targets of the oligoclonal response are still unknown. Identification of these targets will reveal valuable insights into the cause and pathogenesis of MS and is likely to lead to effective treatment.

引用

收藏

页码：786 / 796

页数：11

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