Emerging role of non-coding RNA in oral cancer

被引：135

作者：

Momen-Heravi, Fatemeh ^{[1
]}

Bala, Shashi ^{[2
]}

机构：

[1] Columbia Univ, Coll Dent Med, Div Periodont, Sect Oral & Diagnost Sci, New York, NY 10032 USA

[2] Univ Massachusetts, Sch Med, Dept Med, LRB208,364 Plantat St, Worcester, MA 01605 USA

来源：

CELLULAR SIGNALLING | 2018年 / 42卷

关键词：

lncRNAs; Circular RNAs; miRNAs; Extracellular RNAs; Exosomes; Oral cancer; Oral squamous cell carcinoma; SQUAMOUS-CELL CARCINOMA; LONG-RANGE INTERACTION; CIRCULAR RNAS; MESENCHYMAL TRANSITION; EXTRACELLULAR VESICLES; INCREASED EXPRESSION; COLORECTAL-CANCER; MEMBRANE-VESICLES; POOR-PROGNOSIS; GASTRIC-CANCER;

D O I：

10.1016/j.cellsig.2017.10.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Oral squamous cell carcinoma (OSCC) is characterized by genomic and epigenomic alterations. However, the mechanisms underlying oral squamous cell carcinoma tumorigenesis and progression remain to be elucidated. Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and extracellular RNAs (exRNAs) are emerging groups of regulatory RNAs, which possess low or no protein-coding potential. Emerging lines of evidence indicates that deregulated expression of lncRNAs and circular RNAs are associated with the induction and progression of various cancers, including oral cancer, through epigenetic, transcriptional, and post-transcriptional alterations. In this review, we highlight the expression and functional roles of extracellular RNAs, lncRNAs, and circular RNAs in oral squamous cell carcinoma and discuss their potential clinical applications as diagnostic or prognostic biomarkers, and therapeutic targets.

引用

页码：134 / 143

页数：10

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