Molecular genetics of the caveolin gene family:: Implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy

被引:169
作者
Engelman, JA
Zhang, XL
Galbiati, F
Volonté, D
Sotgia, F
Pestell, RG
Minetti, C
Scherer, PE
Okamoto, T
Lisanti, MP
机构
[1] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
[2] Yeshiva Univ Albert Einstein Coll Med, Albert Einstein Canc Ctr, Bronx, NY 10461 USA
[3] Yeshiva Univ Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA
[4] Yeshiva Univ Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA
[5] Yeshiva Univ Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10461 USA
[6] Univ Genoa, Serv Malattie Neuromuscolari, Gaslini Inst, Genoa, Italy
[7] Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA
关键词
D O I
10.1086/302172
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:1578 / 1587
页数:10
相关论文
共 49 条
[1]   Interaction of a receptor tyrosine kinase, EGF-R, with caveolins - Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities [J].
Couet, J ;
Sargiacomo, M ;
Lisanti, MP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (48) :30429-30438
[2]   Molecular and cellular biology of caveolae - Paradoxes and plasticities [J].
Couet, J ;
Li, SW ;
Okamoto, T ;
Scherer, PE ;
Lisanti, MP .
TRENDS IN CARDIOVASCULAR MEDICINE, 1997, 7 (04) :103-110
[3]   Identification of peptide and protein ligands for the caveolin-scaffolding domain - Implications for the interaction of caveolin with caveolae-associated proteins [J].
Couet, J ;
Li, SW ;
Okamoto, T ;
Ikezu, T ;
Lisanti, MP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) :6525-6533
[4]   Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo - A role for the caveolin-scaffolding domain [J].
Engelman, JA ;
Chu, C ;
Lin, A ;
Jo, H ;
Ikezu, T ;
Okamoto, T ;
Kohtz, DS ;
Lisanti, MP .
FEBS LETTERS, 1998, 428 (03) :205-211
[5]   Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3) - Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/731) [J].
Engelman, JA ;
Zhang, XL ;
Galbiati, F ;
Lisanti, MP .
FEBS LETTERS, 1998, 429 (03) :330-336
[6]   Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers [J].
Engelman, JA ;
Zhang, XL ;
Lisanti, MP .
FEBS LETTERS, 1998, 436 (03) :403-410
[7]   Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo -: Implications for human breast cancer [J].
Engelman, JA ;
Lee, RJ ;
Karnezis, A ;
Bearss, DJ ;
Webster, M ;
Siegel, P ;
Muller, WJ ;
Windle, JJ ;
Pestell, RG ;
Lisanti, MP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (32) :20448-20455
[8]   Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth [J].
Engelman, JA ;
Wykoff, CC ;
Yasuhara, S ;
Song, KS ;
Okamoto, T ;
Lisanti, MP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (26) :16374-16381
[9]   Molecular glue: Kinase anchoring and scaffold proteins [J].
Faux, MC ;
Scott, JD .
CELL, 1996, 85 (01) :9-12
[10]   Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons:: Caveolin-2 is up-regulated in response to cell injury [J].
Galbiati, F ;
Volonté, D ;
Gil, O ;
Zanazzi, G ;
Salzer, JL ;
Sargiacomo, M ;
Scherer, PE ;
Engelman, JA ;
Schlegel, A ;
Parenti, M ;
Okamoto, T ;
Lisanti, MP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :10257-10262