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Proteomics of organelles and large cellular structures

被引：295
作者：
Yates, JR
Gilchrist, A
Howell, KE
Bergeron, JJM
机构：
[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
[2] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 2B2, Canada
[3] Univ Colorado, Sch Med Fitzsimons, Dept Cell & Dev Biol, Aurora, CO 80045 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 09期
基金：
加拿大创新基金会; 美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm1711
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The mass-spectrometry-based identification of proteins has created opportunities for the study of organelles, transport intermediates and large subcellular structures. Traditional cell-biology techniques are used to enrich these structures for proteomics analyses, and such analyses provide insights into the biology and functions of these structures. Here, we review the state-of-the-art proteomics techniques for the analysis of subcellular structures and discuss the biological insights that have been derived from such studies.
引用
收藏
页码：702 / 714
页数：13
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