Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1

被引：36

作者：

Gruffat, H ^{[1
]}

Portes-Sentis, S ^{[1
]}

Sergeant, A ^{[1
]}

Manet, E ^{[1
]}

机构：

[1] Ecole Normale Super Lyon, INSERM, U412, Lab Virol Humaine, F-69364 Lyon 07, France

来源：

JOURNAL OF GENERAL VIROLOGY | 1999年 / 80卷

关键词：

D O I：

10.1099/0022-1317-80-3-557

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Analysis of the recently completed genomic sequence of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) revealed that ORF 50 encodes a protein with homology to the Epstein-Barr virus (EBV) transcription factor R. In this report, we show that ORF K8, contiguous to ORF 50, is interrupted by two introns and that the spliced RNA is translated into a bZip protein that has homology to the EBV transcription factor EB1. The newly characterized K8 protein forms homodimers but does not heterodimerize with other members of the bZip protein family.

引用

页码：557 / 561

页数：5

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