Hepatitis C virus infection-associated markers in sera from blood donors in Surabaya, Indonesia

被引：10

作者：

Darmadi, S

Soetjipto

Handajani, R

Lusida, MI

Soemarto

Sakugawa, H

Ishido, S

Hotta, H

机构：

[1] KOBE UNIV,SCH MED,DEPT MICROBIOL,CHUO KU,KOBE,HYOGO 650,JAPAN

[2] AIRLANGGA UNIV,TROP DIS RES CTR,SURABAYA,INDONESIA

[3] UNIV RYUKYUS,SCH MED,DEPT INTERNAL MED 1,NISHIHARA,OKINAWA 90301,JAPAN

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1996年 / 40卷 / 05期

关键词：

HCV markers; prevalence; blood donor; Indonesia;

D O I：

10.1111/j.1348-0421.1996.tb01086.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Among 2,233 sera obtained from volunteer blood donors, 259 (11.6%) showed elevated alanine aminotransferase (ALT) levels. A second-generation enzyme-linked immunosorbent assay (ELISA) revealed that 23 (8.9%) of the 259 sera were positive for antibodies against hepatitis C virus (HCV), whereas only 9 (1.4%) of 646 sera randomly collected from blood donors with normal ALT levels were positive (P<0.001). The overall prevalence of anti-HCV antibodies among blood donors was estimated to be 2.3%. HCV RNA was detected in 19 (83%) of the 23 anti-HCV-positive sera with elevated ALT levels, and 8 (89%) of the 9 sera with normal ALT levels. Among the anti-HCV-positive sera, IgM anti-HCV was detected in 5 (22%) of 23 sera with elevated ALT levels and in 2 (22%) of 9 sera with normal ALT levels. All of the IgM anti-HCV-positive sera were positive for HCV RNA, irrespective of ALT levels.

引用

页码：401 / 405

页数：5