Normalization of FoxP3+ Regulatory T Cells in Response to Effective Antiretroviral Therapy

被引：34

作者：

Montes, Martin ^{[1
,2
]}

Sanchez, Cesar ^{[2
]}

Lewis, Dorothy E. ^{[3
]}

Graviss, Edward A. ^{[4
]}

Seas, Carlos ^{[2
]}

Gotuzzo, Eduardo ^{[2
]}

White, A. Clinton, Jr. ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Internal Med, Div Infect Dis, Galveston, TX 77555 USA

[2] Univ Peruana Cayetano Heredia, Inst Med Trop Alexander von Humboldt, Lima, Peru

[3] Univ Texas Hlth Sci Ctr, Infect Dis Sect, Dept Med, Houston, TX USA

[4] Methodist Hosp, Ctr Mol & Translat Human Infect Dis Res, Res Inst, Houston, TX 77030 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HIV-INFECTED PATIENTS; IMMUNE ACTIVATION; PERIPHERAL-BLOOD; LYMPHOID-TISSUES; IMMUNOPATHOGENESIS; RECONSTITUTION; POPULATION; HIV/AIDS; DECREASE;

D O I：

10.1093/infdis/jiq073

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4(+)CD25(+)FoxP3(+) T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4(+)CD25(+)FoxP3(+) cells transiently increased and then decreased from a median of 13% at baseline to 5.1% at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate.

引用

页码：496 / 499

页数：4

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