NKT cells in immunoregulation of tumor immunity: a new immunoregulatory axis

被引:115
作者
Terabe, Masaki [1 ]
Berzofsky, Jay A. [1 ]
机构
[1] NCI, Ctr Canc Res, Vaccine Branch, Bethesda, MD 20814 USA
关键词
D O I
10.1016/j.it.2007.05.008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CD1d-restricted natural killer T (NKT) cells have at least two subsets: type I, semi-invariant TCR alpha chain-expressing (V alpha 14J alpha 18 in mice, V alpha 24J alpha 18 in humans), and type II, variable TCR alpha chain-expressing. The protective role of NKT cells in tumor immunosurveillance and immunity has been well documented but paradoxically, there are also studies ascribing a suppressive role to these cells. Recent studies have resolved this paradox by revealing distinct roles for the two types of NKT cells, whereby type I NKT cells enhance anti-tumor responses and type II NKT cells suppress these responses. The finding of cross-regulation between the two types of NKT cells suggests a new immunoregulatory axis. Consideration of the cross-talk of NKT cells along with the well-defined suppression by regulatory T cells could provide new insights into cancer immunotherapy.
引用
收藏
页码:491 / 496
页数:6
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