Asymmetric total synthesis of curacin A

被引：27

作者：

Onoda, T ^{[1
]}

Shirai, R ^{[1
]}

Koiso, Y ^{[1
]}

Iwasaki, S ^{[1
]}

机构：

[1] UNIV TOKYO,INST MOL & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 25期

关键词：

D O I：

10.1016/0040-4039(96)00860-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Curacin A (1), a novel antimitotic agent, was synthesized in a highly stereo-controlled manner. The key steps were (1) an asymmetric allylation using a chiral allyltitanium reagent and a double-asymmetric Simmons-Smith cyclopropanation to introduce three chiral centers, (2) Wittig and Wittig-Horner reactions to construct the C(3-4) and C(7-10) alkenes, and (3) a direct conversion of the thiazolidine to the thiazoline. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：4397 / 4400

页数：4

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