Synthesis of a novel 2′-deoxyuridine derivative bearing a cyanomethoxycarbonylmethyl group at C-5 position and its use for versatile post-synthetic functionalization of oligodeoxyribonucleotides

被引：22

作者：

Kohgo, S ^{[1
]}

Shinozuka, K ^{[1
]}

Ozaki, H ^{[1
]}

Sawai, H ^{[1
]}

机构：

[1] Gunma Univ, Fac Engn, Dept Chem, Kiryu, Gumma 376, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(98)00660-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel 2'-deoxyuridine derivative bearing a cyanomethoxycarbonylmethyl group at the C-5 position (1) was synthesized and its use was examined as a convertible nucleoside for the versatile post-synthesis functionalization of oligodeoxyribonucleotides (ODNs). The ODNs containing 1 reacted with primary monoamines such as heptylamine, histamine, and tyramine as well as di- and polyamines under mild conditions, giving the corresponding derivatized ODNs. (C) 1998 Elsevier Science Ltd. AII rights reserved.

引用

页码：4067 / 4070

页数：4

共 15 条

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