Dispersal of Staphylococcus aureus into the air associated with a rhinovirus infection

被引:55
作者
Bassetti, S
Bischoff, WE
Walter, M
Bassetti-Wyss, BA
Mason, L
Reboussin, BA
D'Agostino, RB
Gwaltney, JM
Pfaller, MA
Sherertz, RJ
机构
[1] Wake Forest Univ, Sch Med, Infect Dis Sect, Winston Salem, NC 27157 USA
[2] Wake Forest Univ, Sch Med, Biostat Sect, Winston Salem, NC 27157 USA
[3] Univ Virginia, Hlth Sci Ctr, Div Epidemiol & Virol, Charlottesville, VA USA
[4] Univ Iowa Hosp & Clin, Div Med Microbiol, Iowa City, IA 52242 USA
关键词
D O I
10.1086/502526
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
OBJECTIVE: To determine whether healthy adult nasal carriers of Staphylococcus aureus can disperse S. aureus into the air after rhinovirus infection. DESIGN: We investigated the "cloud" phenomenon among adult nasal carriers of S. aureus experimentally infected with a rhinovirus. Eleven volunteers were studied for 16 days in an airtight chamber wearing street clothes, sterile garb, or sterile garb plus surgical mask; rhinovirus inoculation occurred on day 2. Daily quantitative air, nasal, and skin cultures for S. aureus; cold symptom assessment; and nasal rhinovirus cultures were performed. SETTING: Wake Forest University School of Medicine, Winston-Salem, North Carolina. PARTICIPANTS: Wake Forest University undergraduate or graduate students who had persistent nasal carriage of S. aureus for 4 or 8 weeks. RESULTS: After rhinovirus inoculation, dispersal of S. aureus into the air increased 2-fold with peak increases tip to 34-fold. Independent predictors of S. aureus dispersal included the time period after rhinovirus infection and wearing street clothes (P < .05). Wearing barrier garb but not a mask decreased dispersal of S. aureus into the air (P < .05). CONCLUSION: Virus-induced dispersal of S. aureus into the air may have an important role in the transmission of S. aureus and other bacteria (Infect Control Hosp Epidemiol 2005;26:196-203).
引用
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页码:196 / 203
页数:8
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