Synthesis of 4-aryl-4,7,8,9-tetrahydro-6H-pyrazolo[3,4-b]quinolin-5-ones

被引：80

作者：

Quiroga, J

Insuasty, B

Hormaza, A

Saitz, C

Jullian, C

机构：

[1] Univ Valle, Dept Chem, Cali, Colombia

[2] Univ Nacl Colombia, Dept Chem, Medellin, Colombia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1998年 / 35卷 / 03期

关键词：

D O I：

10.1002/jhet.5570350313

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 5-amino-3-methyl-1-phenylpyrazole (1a) and 5-amino-3-(4-chlorophenyl)-1H-pyrazole (1b) with dimedone (2) and p-susbstituted benzaldehydes 3 in ethanol, afforded in all cases tricyclic linear 4-aryl- 7,7-dimethyl-4,7,8,9-tetrahydro-6H-pyrazolo[3,4-b] quinolin-5-ones (4a-j) in good yields. The linear structures and hence the regiospecificity of the reaction were established by nmr measurements.

引用

页码：575 / 578

页数：4

共 11 条

[1]

Bell M.R., US Patent, Patent No. [4920,128, 4920128]

[2]

CAMPBELL JB, Patent No. 141608

[3] POTENTIAL CYTOSTACTICS .16. BICYCLIC SYSTEMS FROM DIACETIC ETHER AND 5-AMINO-1-METHYL-5-AMINO-1-BENZYL-AND 3(5)-AMINOPYRAZOLE [J].