Synthesis of pyrimido[4,5-b]quinolines in the reaction of 6-aminopyrimidines with dimedone and benzaldehydes

被引:57
作者
Quiroga, J [1 ]
Hormaza, A
Insuasty, B
Ortiz, AJ
Sanchez, A
Nogueras, M
机构
[1] Univ Valle, Dept Chem, Cali AA25360, Colombia
[2] Univ Jaen, Dept Inorgan & Organ Chem, Jaen 23071, Spain
关键词
D O I
10.1002/jhet.5570350142
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The reaction of 6-aminopyrimidines 1a,b with dimedone (2) and p-substituted benzaldehydes 3a-d in ethanol afforded in all cases new regiospecific synthesis of tricyclic, linear 5-aryl-5,6,7,8,9,10-hexahydropyrimido[4,5-b]quinolines 4a-h in good yields, The linear structures and hence the regiospecificity of the reaction were established by nmr measurements.
引用
收藏
页码:231 / 233
页数:3
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