Cytokine profiles in drug-naive schizophrenic patients

被引：65

作者：

Cazzullo, CL

Sacchetti, E

Galluzzo, A

Panariello, A

Colombo, F

Zagliani, A

Clerici, M

机构：

[1] Fdn Legrenzi, Assoc Res Schizophrenia, I-20124 Brescia, Italy

[2] Univ Brescia, Sch Med, Inst Psychiat, Brescia, Italy

[3] Univ Milan, Dept Immunol, L Sacco Hosp Vialba, Milan, Italy

来源：

SCHIZOPHRENIA RESEARCH | 2001年 / 47卷 / 2-3期

关键词：

D O I：

10.1016/S0920-9964(00)00046-3

中图分类号：

R749 [精神病学];

学科分类号：

100205 [精神病与精神卫生学];

摘要：

A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-gamma] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-gamma was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities art: present in some schizophrenic patients. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

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页码：293 / 298

页数：6

相关论文

共 27 条

[1]

CYTOKINE PRODUCTION IN DRUG-FREE AND NEUROLEPTIC-TREATED SCHIZOPHRENIC-PATIENTS [J].

BESSLER, H ;

LEVENTAL, Z ;

KARP, L ;

MODAI, I ;

DJALDETTI, M ;

WEIZMAN, A .

BIOLOGICAL PSYCHIATRY, 1995, 38 (05) :297-302

[2]

Increased levels of CD8+ and CD4+45RA+ lymphocytes in schizophrenic patients [J].

Cazzullo, CL ;

Saresella, M ;

Roda, K ;

Calvo, MG ;

Bertrando, P ;

Doria, S ;

Clerici, M ;

Salvaggio, A ;

Ferrante, P .

SCHIZOPHRENIA RESEARCH, 1998, 31 (01) :49-55

[3]

Cytokines production in chronic schizophrenia patients with or without paranoid behaviour [J].

Cazzullo, CL ;

Scarone, S ;

Grassi, B ;

Vismara, C ;

Trabattoni, D ;

Clerici, M ;

Clerici, M .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1998, 22 (06) :947-957

[4]

CAZZULLO CL, 1996, REND I LOMBARDO ACCA, V129, P289

[5]

DELISI LE, 1982, BIOL PSYCHIAT, V17, P1003

[6]

THE NEUROPSYCHIATRIC EFFECTS OF TREATMENT WITH INTERLEUKIN-2 AND LYMPHOKINE-ACTIVATED KILLER-CELLS [J].

DENICOFF, KD ;

RUBINOW, DR ;

PAPA, MZ ;

SIMPSON, C ;

SEIPP, CA ;

LOTZE, MT ;

CHANG, AE ;

ROSENSTEIN, D ;

ROSENBERG, SA .

ANNALS OF INTERNAL MEDICINE, 1987, 107 (03) :293-300

[7]

CLINICAL AND LABORATORY EVIDENCE OF AUTOIMMUNITY IN ACUTE SCHIZOPHRENIA [J].

GANGULI, R ;

RABIN, BS ;

KELLY, RH ;

LYTE, M ;

RAGU, U .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 496 :676-685

[8]

GANGULI R, 1989, ARCH GEN PSYCHIAT, V46, P292

[9]

SERUM INTERLEUKIN-6 CONCENTRATION IN SCHIZOPHRENIA - ELEVATION ASSOCIATED WITH DURATION OF ILLNESS [J].

GANGULI, R ;

YANG, ZW ;

SHURIN, G ;

CHENGAPPA, KNR ;

BRAR, JS ;

GUBBI, AV ;

RABIN, BS .

PSYCHIATRY RESEARCH, 1994, 51 (01) :1-10

[10]

LYMPHOCYTE-T SUBPOPULATIONS IN SCHIZOPHRENIC-PATIENTS [J].

HENNEBERG, A ;

RIEDL, B ;

DUMKE, HO ;

KORNHUBER, HH .

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 1990, 239 (05) :283-284