Specificity in signaling pathways: assembly into multimolecular signaling complexes

被引：35

作者：

Tsunoda, S ^{[1
]}

Sierralta, J

Zuker, CS

机构：

[1] Univ Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0959-437X(98)80112-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A critical issue in the field of signal transduction is how signaling molecules are organized into different pathways within the same cell. The importance of assembling signaling molecules into architecturally defined complexes is emerging as an essential cellular strategy to ensure specificity and selectivity of signaling. Scaffold proteins function as the pillars of these transduction complexes, bringing together a diversity of signaling components into defined ultramicrodomains of signaling.

引用

页码：419 / 422

页数：4

共 39 条

[21] Pheromone signalling and polarized morphogenesis in yeast [J].

Leberer, E ;

Thomas, DY ;

Whiteway, M .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1997, 7 (01) :59-66

[22] THE PROLIFERATION OF MAP KINASE SIGNALING PATHWAYS IN YEAST [J].

LEVIN, DE ;

ERREDE, B .

CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (02) :197-202

[23] CLONING AND CHARACTERIZATION OF HDLG - THE HUMAN HOMOLOG OF THE DROSOPHILA DISKS LARGE TUMOR-SUPPRESSOR BINDS TO PROTEIN-4.1 [J].

LUE, RA ;

MARFATIA, SM ;

BRANTON, D ;

CHISHTI, AH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :9818-9822

[24]

MARCHESI VT, 1985, ANNU REV CELL BIOL, V1, P531, DOI 10.1146/annurev.cb.01.110185.002531

[25] The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C - Analysis of the binding interface by in vitro mutagenesis [J].

Marfatia, SM ;

MoraisCabral, JH ;

Kim, AC ;

Byron, O ;

Chishti, AH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (39) :24191-24197

[26] CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90 [J].

Niethammer, M ;

Valtschanoff, JG ;

Kapoor, TM ;

Allison, DW ;

Weinberg, RJ ;

Craig, AM ;

Sheng, M .

NEURON, 1998, 20 (04) :693-707

[27] Signaling through scaffold, anchoring, and adaptor proteins [J].

Pawson, T ;

Scott, JD .

SCIENCE, 1997, 278 (5346) :2075-2080

[28] PDZ domains: Targeting signalling molecules to sub-membranous sites [J].

Ponting, CP ;

Phillips, C ;

Davies, KE ;

Blake, DJ .

BIOESSAYS, 1997, 19 (06) :469-479

[29] PDZs and receptor/channel clustering: Rounding up the latest suspects [J].

Sheng, M .

NEURON, 1996, 17 (04) :575-578

[30] Association of INAD with NORPA is essential for controlled activation and deactivation of Drosophila phototransduction in vivo [J].

Shieh, BH ;

Zhu, MY ;

Lee, JK ;

Kelly, IM ;

Bahiraei, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (23) :12682-12687

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