Highly enantioselective organocatalytic conjugate addition of nitromethane to α,β-unsaturated aldehydes:: Three-step synthesis of optically active baclofen

被引：114

作者：

Zu, Liansuo ^{[1
]}

Xie, Hexin ^{[1
]}

Li, Hao ^{[1
]}

Wang, Han ^{[1
]}

Wang, Wei ^{[1
]}

机构：

[1] Univ New Mexico, Dept Chem & Biol Chem, Albuquerque, NM 87131 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 17-18期

关键词：

asymmetric catalysis; asymmetric synthesis; C-C bond formation; Michael addition; organic; catalysis;

D O I：

10.1002/adsc.200700353

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient, organocatalytic, highly enantioselective, conjugate addition reaction of nitromethane with a,p-unsaturated aldehydes has been developed. The process serves as the key step for a practical 3-step synthesis of chiral baclofen, an antispastic drug.

引用

页码：2660 / 2664

页数：5

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