Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog

被引:1201
作者
Kappe, CO [1 ]
机构
[1] Graz Univ, Inst Chem, A-8010 Graz, Austria
关键词
D O I
10.1021/ar000048h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In 1893, P. Biginelli reported the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via three-component condensation reaction of an aromatic aldehyde, urea, and ethyl acetoacetate. In the past decade, this long-neglected multicomponent reaction has experienced a remarkable revival, mainly due to the interesting pharmacological properties associated with this dihydropyrimidine scaffold. In this Account, we highlight recent developments in the Biginelli reaction in areas such as solid-phase synthesis, combinatorial chemistry, and natural product synthesis.
引用
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页码:879 / 888
页数:10
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