Epigenetics Gets Sweeter: O-GlcNAc Joins the "Histone Code"

被引：33

作者：

Hanover, John A. ^{[1
]}

机构：

[1] NIDDK, Cellular & Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

CHEMISTRY & BIOLOGY | 2010年 / 17卷 / 12期

关键词：

TETRATRICOPEPTIDE REPEATS; N-ACETYLGLUCOSAMINE; TRANSFERASE; GLYCOSYLATION; CHROMATIN; PROTEINS; GENE;

D O I：

10.1016/j.chembiol.2010.12.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

O-GlcNAcylation has now been added to the growing list of histone modifications making up the multifaceted "histone-code" (Sakabe et al., 2010). The sites of O-GlcNAc-histone modification hint at a role in chromatin remodeling, thus adding to mounting evidence that O-GlcNAc cycling sits atop a robust regulatory network maintaining higher-order chromatin structure and epigenetic memory.

引用

页码：1272 / 1274

页数：3

共 12 条

[1] O-linked β-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress [J].

Butkinaree, Chutikarn ;

Park, Kyoungsook ;

Hart, Gerald W. .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2010, 1800 (02) :96-106

[2] Tup1-Ssn6 and Swi-Snf remodelling activities influence long-range chromatin organization upstream of the yeast SUC2 gene [J].

Fleming, Alastair B. ;

Pennings, Sari .

NUCLEIC ACIDS RESEARCH, 2007, 35 (16) :5520-5531

[3] Essential Role of the Glycosyltransferase Sxc/Ogt in Polycomb Repression [J].

Gambetta, Maria Cristina ;

Oktaba, Katarzyna ;

Mueller, Juerg .

SCIENCE, 2009, 325 (5936) :93-96

[4] The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine [J].

Hanover, John A. ;

Krause, Michael W. ;

Love, Dona C. .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2010, 1800 (02) :80-95

[5] Translating the histone code [J].

Jenuwein, T ;

Allis, CD .

SCIENCE, 2001, 293 (5532) :1074-1080

[6] GLYCOSYLATION OF CHROMOSOMAL-PROTEINS - LOCALIZATION OF O-LINKED N-ACETYLGLUCOSAMINE IN DROSOPHILA CHROMATIN [J].

KELLY, WG ;

HART, GW .

CELL, 1989, 57 (02) :243-251

[7]

Kreppel LK, 1997, J BIOL CHEM, V272, P9308

[8] O-GlcNAc cycling: Emerging roles in development and epigenetics [J].

Love, Dona C. ;

Krause, Michael W. ;

Hanover, John A. .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2010, 21 (06) :646-654

[9] Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity [J].

Love, Dona C. ;

Ghosh, Salil ;

Mondoux, Michelle A. ;

Fukushige, Tetsunari ;

Wang, Peng ;

Wilson, Mark A. ;

Iser, Wendy B. ;

Wolkow, Catherine A. ;

Krause, Michael W. ;

Hanover, John A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (16) :7413-7418

[10]

Lubas WA, 1997, J BIOL CHEM, V272, P9316

← 1 2 →