Reactions catalyzed by bacterial cytochromes P450

被引:95
作者
Cryle, MJ [1 ]
Stok, JE [1 ]
De Voss, JJ [1 ]
机构
[1] Univ Queensland, Dept Chem, Brisbane, Qld 4072, Australia
关键词
D O I
10.1071/CH03040
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The cytochromes P450 are a large family of oxidative haemoproteins that are responsible for a wide variety of oxidative transformations in a variety of organisms. This review focuses upon the reactions catalyzed specifically by bacterial enzymes, which includes aliphatic hydroxylation, alkene epoxidation, aromatic hydroxylation, oxidative phenolic coupling, heteroatom oxidation and dealkylation, and multiple oxidations including C-C bond cleavage. The potential for the practical application of the oxidizing power of these enzymes is briefly discussed.
引用
收藏
页码:749 / 762
页数:14
相关论文
共 129 条
  • [1] SUBSTRATE-SPECIFICITY OF 6-DEOXYERYTHRONOLIDE-B HYDROXYLASE, A BACTERIAL CYTOCHROME-P450 OF ERYTHROMYCIN-A BIOSYNTHESIS
    ANDERSEN, JF
    TATSUTA, K
    GUNJI, H
    ISHIYAMA, T
    HUTCHINSON, CR
    [J]. BIOCHEMISTRY, 1993, 32 (08) : 1905 - 1913
  • [2] Flexibility and stability of the structure of cytochromes P450 3A4 and BM-3
    Anzenbacherová, E
    Bec, N
    Anzenbacher, P
    Hudecek, J
    Soucek, P
    Jung, C
    Munro, AW
    Lange, R
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (10): : 2916 - 2920
  • [3] Aoyama Y, 1998, J BIOCHEM-TOKYO, V124, P694
  • [4] Butane and propane oxidation by engineered cytochrome P450cam
    Bell, SG
    Stevenson, JA
    Boyd, HD
    Campbell, S
    Riddle, AD
    Orton, EL
    Wong, LL
    [J]. CHEMICAL COMMUNICATIONS, 2002, (05) : 490 - 491
  • [5] Engineering the CYP101 system for in vivo oxidation of unnatural substrates
    Bell, SG
    Harford-Cross, CF
    Wong, LL
    [J]. PROTEIN ENGINEERING, 2001, 14 (10): : 797 - 802
  • [6] Characterization and catalytic properties of the sterol 14α-demethylase from Mycobacterium tuberculosis
    Bellamine, A
    Mangla, AT
    Nes, WD
    Waterman, MR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) : 8937 - 8942
  • [7] Microbial transformations of steroids-XI.: Progesterone transformation by Streptomyces roseochromogenes-purification and characterisation of the 16α-hydroxylase system
    Berrie, JR
    Williams, RAD
    Smith, KE
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1999, 71 (3-4) : 153 - 165
  • [8] Characterization of the macrolide P-450 hydroxylase from Streptomyces venezuelae which converts narbomycin to picromycin
    Betlach, MC
    Kealey, JT
    Betlach, MC
    Ashley, GW
    McDaniel, R
    [J]. BIOCHEMISTRY, 1998, 37 (42) : 14937 - 14942
  • [9] BACTERIAL DEGRADATION OF DEHYDROABIETIC ACID BY A PSEUDOMONAS AND AN ALCALIGENES
    BIELLMANN, JF
    BRANLANT, G
    GEROROBE.M
    POIRET, M
    [J]. TETRAHEDRON, 1973, 29 (09) : 1237 - 1241
  • [10] BACTERIAL DEGRADATION OF DEHYDROABIETIC ACID BY FLAVOBACTERIUM-RESINOVORUM
    BIELLMANN, JF
    BRANLANT, G
    GEROROBE.M
    POIRET, M
    [J]. TETRAHEDRON, 1973, 29 (09) : 1227 - 1236