Synthesis and antimycobacterial activity of capuramycin analogues. Part 1: Substitution of the azepan-2-one moiety of capuramycin

被引：45

作者：

Hotoda, H

Furukawa, M

Daigo, M

Murayama, K

Kaneko, M

Muramatsu, Y

Ishii, MM

Miyakoshi, S

Takatsu, T

Inukai, M

Kakuta, M

Abe, T

Harasaki, T

Fukuoka, T

Utsui, Y

Ohya, S

机构：

[1] Sankyo Co Ltd, New Drug Dev Div, Drug Safety Dept, Shinagawa Ku, Tokyo 1408710, Japan

[2] Sankyo Co Ltd, Biomed Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 17期

关键词：

TRANSLOCASE-I INHIBITORS; A-500359; FERMENTATION; TAXONOMY;

D O I：

10.1016/S0960-894X(03)00596-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Capuramycin analogues with a variety of substituents in place of the azepan-2-one moiety were synthesized from A-500359E and were tested for their translocase I inhibitory activity and in vitro antimycobacterial activity. Phenyl-type moieties were found to be effective substituents for capuramycin analogues. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：2829 / 2832

页数：4

共 12 条

[1]

Boyle DS, 1998, J BACTERIOL, V180, P6429

[2]

DOI N, UNPUB ANTIMICROB AGE

[3]

Grassi C, 1997, Expert Opin Investig Drugs, V6, P1211, DOI 10.1517/13543784.6.9.1211

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