The potential of virulent Wolbachia to modulate disease transmission by insects

被引:101
作者
Brownstin, JS
Hett, E
O'Neill, SL [1 ]
机构
[1] Univ Queensland, Sch Life Sci, Dept Zool & Entomol, St Lucia, Qld 4072, Australia
[2] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA
关键词
Wolbachia; dengue; Aedes aegypti; mosquito; vector-borne disease; genetic manipulation; age structure;
D O I
10.1016/S0022-2011(03)00082-X
中图分类号
Q95 [动物学];
学科分类号
071002 ;
摘要
A virulent strain of Wolbachia has recently been identified in Drosophila that drastically reduces adult lifespan. It has been proposed that this phenotype might be introduced into insect disease vector populations to reduce pathogen transmission. Here we model the requirements for spread of such an agent and the associated reduction in disease transmission. First, a simulation of mosquito population age structure was used to describe the age distribution of mosquitoes transmitting dengue virus. Second, given varying levels of cytoplasmic incompatibility and fecundity effect, the maximum possible longevity reduction that would allow Wolbachia to invade was obtained. Finally, the two models were combined to estimate the reduction in disease transmission according to different introduction frequencies, With strong Cl and limited effect of fecundity, an introduction of Wolbachia with an initial frequency of 0.4 could result in a 60-80% reduction of transmitting mosquitoes. Greater reductions are possible at higher initial release rates. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:24 / 29
页数:6
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