Suppression of alcohol delirium tremens by baclofen administration: A case report

被引：46

作者：

Addolorato, G

Leggio, L

Abenavoli, L

DeLorenzi, G

Parente, A

Caputo, F

Janiri, L

Capristo, E

Rapaccini, GL

Gasbarrini, G

机构：

[1] Univ Cattolica Sacro Cuore, Inst Internal Med, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dept Psychiat, I-00168 Rome, Italy

[3] Univ Bologna, G Fontana Ctr Study & Treatment Alcohol Addict, Bologna, Italy

来源：

CLINICAL NEUROPHARMACOLOGY | 2003年 / 26卷 / 05期

关键词：

delirium tremens; GABA(B); receptor agonist; baclofen;

D O I：

10.1097/00002826-200309000-00010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Delirium tremens (DT) is a clinical condition that appears in some patients affected by severe alcohol withdrawal syndrome (AWS). DT represents a serious complication, being characterized by elevated morbidity and mortality. Benzodiazepines are presently the drug of choice; however their use is related to several side effects. Baclofen is a stereoselective gamma-aminobutyric acid (GABA(B)) receptor agonist. Recent studies show that baclofen is able to suppress alcohol withdrawal symptoms. At present there are no data on the effects of baclofen administration in AWS complicated by DT. Here, we report a case of DT successfully treated with baclofen. This result indicates that the efficacy of baclofen in the treatment of DT should be examined in future clinical trials.

引用

页码：258 / 262

页数：5

共 22 条

[11] The alcohol withdrawal syndrome
Hall, W
Zador, D
[J]. LANCET, 1997, 349 (9069) : 1897 - 1900
[12] Hersh D, 1997, AM J PSYCHIAT, V154, P846
[13] HOEY LL, 1994, PHARMACOTHERAPY, V14, P579
[14] NMDA RECEPTORS - ROLE IN ETHANOL WITHDRAWAL SEIZURES
HOFFMAN, PL
GRANT, KA
SNELL, LD
REINLIB, L
IORIO, K
TABAKOFF, B
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 654 : 52 - 60
[15] Holbrook AM, 1999, CAN MED ASSOC J, V160, P675
[16] Benzodiazepine treatment for alcohol-dependent patients
Lejoyeux, M
Solomon, J
Adès, J
[J]. ALCOHOL AND ALCOHOLISM, 1998, 33 (06): : 563 - 575
[17] Pharmacological management of alcohol withdrawal - A meta-analysis and evidence-based practice guideline
MayoSmith, MF
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (02): : 144 - 151
[18] A PHYSIOLOGICAL-ROLE FOR GABA(B) RECEPTORS AND THE EFFECTS OF BACLOFEN IN THE MAMMALIAN CENTRAL-NERVOUS-SYSTEM
MISGELD, U
BIJAK, M
JAROLIMEK, W
[J]. PROGRESS IN NEUROBIOLOGY, 1995, 46 (04) : 423 - 462
[19] BENZODIAZEPINE USE AND ANXIOLYTIC ABUSE AND DEPENDENCE IN TREATED ALCOHOLICS
ROSS, HE
[J]. ADDICTION, 1993, 88 (02) : 209 - 218
[20] SULLIVAN JT, 1989, BRIT J ADDICT, V84, P1353

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