Effects of nucleoid-associated proteins on bacterial chromosome structure and gene expression

被引：230

作者：

Browning, Douglas F. ^{[2
]}

Grainger, David C. ^{[3
]}

Busby, Stephen J. W. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Sch Immun & Infect, Birmingham B15 2TT, W Midlands, England

[3] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England

来源：

CURRENT OPINION IN MICROBIOLOGY | 2010年 / 13卷 / 06期

基金：

英国惠康基金;

关键词：

ESCHERICHIA-COLI CHROMOSOME; GENOME-WIDE ANALYSIS; H-NS; MYCOBACTERIUM-TUBERCULOSIS; TRANSCRIPTIONAL REGULATION; OCCUPANCY LANDSCAPE; BINDING-PROTEIN; HIGH-AFFINITY; FIS PROTEIN; IN-VITRO;

D O I：

10.1016/j.mib.2010.09.013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacterial nucleoid-associated proteins play a key role in the organisation, replication, segregation, repair and expression of bacterial chromosomes. Here, we review some recent progress in our understanding of the effects of these proteins on DNA and their biological role, focussing mainly on Escherichia coli and its chromosome. Certain nucleoid-associated proteins also regulate transcription initiation at specific promoters, and work in concert with dedicated transcription factors to regulate gene expression in response to growth phase and environmental change. Some specific examples, involving the E. coli IHF and Fis proteins, that illustrate new principles, are described in detail.

引用

页码：773 / 780

页数：8