We examine the structure of soft supersymmetry breaking terms in KKLT models of flux compactification with low energy supersymmetry. Moduli are stabilized by fluxes and nonperturbative dynamics while a de Sitter vacuum is obtained by adding supersymmetry breaking anti-branes. We discuss the characteristic pattern of mass scales in such a set-up as well as some features of 4D N = 1 supergravity breakdown by anti-branes. Anomaly mediation is found to always give an important contribution and one can easily arrange for flavor-independent soft terms. In its most attractive realization, the modulus mediation is comparable to the anomaly mediation, yielding a quite distinctive sparticle spectrum. In addition, the axion component of the modulus/dilaton superfield dynamically cancels the relative CP phase between the contributions of anomaly and modulus mediation, thereby avoiding dangerous SUSY CP violation. (c) 2005 Elsevier B.V. All rights reserved.