Anti-HBV activities of Streblus asper and constituents of its roots

被引：36

作者：

Chen, Hong ^{[1
,2
]}

Li, Jun ^{[1
,2
]}

Wu, Qiang ^{[2
]}

Niu, Xiao-Tao ^{[2
]}

Tang, Mao-Tong ^{[1
,3
]}

Guan, Xin-Lan ^{[4
]}

Li, Jian ^{[4
]}

Yang, Rui-Yun ^{[2
]}

Deng, Sheng-Ping ^{[2
]}

Su, Xiao-Jian ^{[1
,3
]}

机构：

[1] Guangxi Normal Univ, Sch Environm & Resource, Minist Educ China, Key Lab Ecol Rare & Endangered Species & Environm, Guilin 541004, Peoples R China

[2] Minist Educ China, Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

[3] Guangxi Key Lab Environm Engn Protect & Assessmen, Guilin 541004, Peoples R China

[4] Peoples Hosp Pubei, Pubei 535300, Peoples R China

来源：

FITOTERAPIA | 2012年 / 83卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Moraceae; Streblus asper; (7R,85,7 ' R,8 ' S)-erythro-strebluslignanol H; Anti-HBV activity; LIGNANS; HEARTWOOD;

D O I：

10.1016/j.fitote.2012.01.009

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The extracts from leaves, heartwood, barks and roots of the Streblus asper were investigated for anti-HBV activities, separately. The results suggested that the MeOH extracts of the heartwood, barks, and roots exhibited good anti-HBV activities. Further investigations displayed that ethyl acetate and n-butanol soluble parts of their MeOH extracts showed more significant anti-HBV activities. Moreover, a new lignan, together with 11 known compounds, was isolated from n-butanol-soluble part of MeOH extract of the roots of S. asper. The structures were elucidated by spectroscopic methods, including ID NMR (H-1 NMR, C-13 NMR), 2D NMR (HMQC, HMBC) and HR-EI-MS experiments. Compounds 1-3 were evaluated for their anti-HBV activities. Honokiol showed significant anti-HBV activity with IC50 values of 3.14 mu M and 4.74 mu M for HBsAg and HBeAg with no cytotoxicity respectively, while lamivudine (3TC, positive control) exhibited weak anti-HBV activity with IC50 values of 11.81 mu M and 25.80 mu M for HBsAg and HBeAg respectively. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：643 / 649

页数：7

共 30 条

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[Anonymous], ECAM ADV ACC

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